Complementary Therapies in Medicine
Volume 18, Issue 3 , Pages 171-174 , June 2010

Fish oil supplementation increases the cyclooxygenase inhibitory activity of paracetamol in rheumatoid arthritis patients

  • Gillian E. Caughey

      Affiliations

    • Quality Use of Medicines and Pharmacy Research Centre (QUMPRC), Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide 5001, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 8 8302 1749; fax: +61 8 8302 1087.
    • ,
  • Michael J. James

      Affiliations

    • Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
    • ,
  • Susanna M. Proudman

      Affiliations

    • Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
    • ,
  • Leslie G. Cleland

      Affiliations

    • Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia

References 

  1. van der Linden MW, van der Bij S, Welsing P, Kuipers EJ, Herings RM. The balance between severe cardiovascular and gastrointestinal events among users of selective and non-selective non-steroidal anti-inflammatory drugs. Ann Rheum Dis. 2009;68:668–673
  2. National Prescribing Service . Elevated cardiovascular risk with NSAIDs?. 2005;
  3. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines . Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum. 2000;43:1905–1915
  4. Towheed TE, Maxwell L, Judd MG, Catton M, Hochberg MC, Wells G. Acetaminophen for osteoarthritis. Cochrane Database Syst Rev. 2006;25:CD004257
  5. National Prescribing Service . NPS News 47: Analgesic options for pain relief. 2006;
  6. Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain. 2007;129:210–223
  7. von Schacky C, Harris WS. Cardiovascular benefits of omega-3 fatty acids. Cardiovasc Res. 2007;73:310–315
  8. Cleland LG, James MJ, Proudman SM. Fish oil: what the prescriber needs to know. Arthritis Res Ther. 2005;8:202
  9. Hanel AM, Lands WEM. Modification of anti-inflammatory drug effectiveness by ambient lipid peroxides. Biochem Pharmacol. 1982;31:3307–3311
  10. Smith WL, Lands WE. Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland. Biochemistry. 1972;11:3276–3285
  11. Proudman SM, Cleland LG, James MJ. Dietary omega-3 fats for treatment of inflammatory joint disease: efficacy and utility. Rheum Dis Clin North Am. 2008;34:469–479
  12. Lands WE. Biosynthesis of prostaglandins. Annu Rev Nutr. 1991;11:41–60
  13. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–324
  14. Proudman SM, Keen HI, Stamp LK, Lee AT, Goldblatt F, Ayres OC, et al. Response-driven combination therapy with conventional disease-modifying antirheumatic drugs can achieve high response rates in early rheumatoid arthritis with minimal glucocorticoid and nonsteroidal anti-inflammatory drug use. Semin Arthritis Rheum. 2007;37:99–111
  15. Cleland LG, Caughey GE, James MJ, Proudman SM. Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritis. J Rheumatol. 2006;33:1973–1979
  16. Caughey GE, Cleland LG, Penglis PS, Gamble JR, James MJ. Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2. J Immunol. 2001;167:2831–2838
  17. Meyer BJ, Mann NJ, Lewis JL, Milligan GC, Sinclair AJ, Howe PR. Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids. 2003;38:391–398
  18. Van Hecken A, Schwartz JI, Depre M, De Lepeleire I, Dallob A, Tanaka W, et al. Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol. 2000;40:1109–1120

PII: S0965-2299(10)00069-5

doi: 10.1016/j.ctim.2010.05.032

Complementary Therapies in Medicine
Volume 18, Issue 3 , Pages 171-174 , June 2010

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